Biofunctional surfaces and bioanalysis
Surfaces play a central role in nature and in most technical applications. With implants, for example, the attachment of selected molecules to the surface ensures high biocompatibility and simultaneous protection against harmful germs. In medical diagnostics the attachment of proteins or cells to surfaces is also particularly important.
At the same time, however, there are many applications involving surfaces where interaction with biological materials is undesired. These include, for example, the non-specific adsorption of proteins on pharmaceutical packaging, on implants, in the area of sensor surfaces, and on technical surfaces such as the hulls of ships (“anti-fouling”).
Interdisciplinary research projects involving various sections of the Fraunhofer IFAM and national as well as international partners are being undertaken to address these issues. Newly developed materials respectively surface modifications are qualified by carrying out analytical, microbiological, or cell-biology tests following existing standards.
- Surface modification for medical technology
- Surfaces with antibacterial properties, e. g., via peptides
- Customized surface interaction of proteins and cells, e. g., for diagnostics
- Biocompatible surfaces, e. g., for implants
- Biofunctionalized nanoparticles
- Determination of peptide and protein adsorption on surfaces using, e. g., QCM-D technology
- Secondary structural analysis of peptides and proteins in solution and on surfaces using, e. g., FTIR spectroscopy
- Surface analysis for medical technology